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Does Growth Hormone Benefit People with Metabolic Syndrome?

HGH and metabolic syndrome

What is Metabolic Syndrome?


Metabolic syndrome or MetS is a cluster of conditions, including high blood sugar, insulin resistance, hypertension, dyslipidemia (abnormal blood lipid levels), obesity, and pro-inflammation, that occur together, increasing risk of cardiovascular disease and type-2 diabetes.


MetS is a multifactorial disease that is increasingly common in adults. Yet it has been found to be associated with the imbalance of metabolism.

Human growth hormone (HGH) is a hormone produced by the pituitary gland to enhance growth and cell repair. Another crucial function of HGH is to maintain metabolic balance – the breakdown and regenesis of fat, carbohydrate, and protein – reducing the risk of metabolic syndrome.

The Effects of HGH on Metabolic Syndrome

HGH also plays an important role in macronutrient metabolism. One study reported that young adults with childhood-onset growth hormone deficiency had larger waist circumference, higher blood pressure, higher triglyceride levels, and higher prevalence of metabolic syndrome.

According to one clinical study in obese men, low levels of HGH replacement could reduce their total body fat and visceral adipose tissue, moreover, improve insulin sensitivity. HGH has been suggested to exert various benefits for metabolic syndrome, including:

  • Preventing type-2 diabetes: The development of type-2 diabetes is directly related to insulin resistance. HGH and IGF1 shown to improve insulin sensitivity, thus decreasing the risk of type-2 diabetes.
  • Improving dyslipidemia: HGH can stimulate fat breakdown, decreasing body fat accumulation, as well as LDL-cholesterol and triglyceride levels. As a result, the negative consequences of dyslipidemia are subsided. 
  • Preventing obesity: Increased body weight and waist circumference leads to a greater risk of metabolic syndrome. As HGH induces fat breakdown, it limits your chance to become obese.
  • Reducing the risk of cardiovascular disease: HGH can diminish several cardiovascular risk factors, including dyslipidemia, obesity, and insulin resistance, preventing the development of the cardiovascular disease.

How to boost HGH

There are several ways to naturally boost HGH levels, such as more exercise, losing body fat, or taking supplements. However, for individuals who have growth hormone deficiency (GHD), the most effective treatment is to inject recombinant growth hormone (rHGH) directly under the skin.

Recombinant HGH or rHGH is a synthetic copy of growth hormone used for the replacement of HGH in people of all ages who have GHD and other related diseases, including Prader-Willi syndrome, Turner syndrome, Small for gestational age, and Idiopathic short stature. 

There are various FDA-approved rHGH products available in the market, for example, GENOTROPIN – a product of Pfizer which has treated people who need HGH replacement for over 30 years.

GENOTROPIN 36 IU GoQuick Pen is a portable option of GENOTROPIN in a disposable pre-filled pen form, which is very easy to learn how to use. As this is a prescription product, please consult the doctor about your concerns beforehand. 

  • Lim, H. H., Kang, M. J., Yun, I. S., Lee, Y. A., Shin, C. H., & Yang, S. W. (2010). Prevalence and risk factors of the metabolic syndrome in young adults with childhood-onset hypopituitary growth hormone deficiency. Korean journal of pediatrics53(10), 892–897. doi:10.3345/kjp.2010.53.10.892
  • Johannsson G, Bengtsson BA. Growth hormone and the metabolic syndrome. J Endocrinol Invest. 1999;22:41–46.
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