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Nebido – The Long-Lasting Testosterone

Nebido – The Long-Lasting Testosterone

The following article revolves around the following product:

Bayer Nebido 1000mg/4ml, Solution for Injection


Due to frequent regulatory changes, the information you find here may vary from the content found in your package’s Patient Information Leaflet. It is advised to compare the medicine pack’s manufacturing date in your leaflet to establish whether there have been any changes afterwards.

If you still have any doubts or queries regarding your medication, you can contact your doctor or a pharmacist for further clarification.

Important Information for the Users

Please read the following medical guide carefully before using Bayer Nebido on your doctor’s order, as it may contain important information for you. Before we start, it’s crucial to remember the following points:

  1. It is advised to keep this medical guide on hand since you may need to read it again for different purposes.
  2. If you have any further questions regarding the product after going through this leaflet, we advise you to consult with your doctor only.
  3. Bayer Nebido has been prescribed by your doctor for only you. Please don’t pass it on to others you may know, even if their signs of illness match yours. Not considering the doctor’s opinion can put the users in harm’s way.
  4. If you experience any unusual side effects due to the medicine, it is recommended to talk to your doctor immediately. You can refer to section 4 of this article for a detailed analysis.

What You’ll Find in This Medical Guide?

  1. What is Nebido, and What Is It Used for?
  2. Things You Need to Know Before Using Nebido
  3. How to Use Nebido?
  4. Possible Side Effects of Using Nebido
  5. How to Store Nebido?

1- What Is Nebido, and What Is It Used for?

Nebido is an oily, yellowish liquid whose active ingredient is testosterone, a male hormone. The medicine is injected into a muscle in your body when it suffers from a natural deficiency of the said hormone, acting as the long-lasting testosterone. After being injected into the muscle, the medicine remains stored there for a while as it is gradually released into the body. 

Generally, Nebido is recommended for adult men as a testosterone replacement for treating several health-related issues caused due to a lack of testosterone, also known as male hypogonadism. This condition can be easily confirmed by a set of two separate blood testosterone measurements. Moreover, individuals dealing with such medical conditions usually experience the following clinical symptoms before treatment:

2- Things You Need to Know Before Using Nebido

It is prohibited to use Bayer Nebido if:

  1. You’re allergic to testosterone undecanoate or other ingredients present in Nebido, including benzyl benzoate and refined castor oil.
  2. You’ve androgen-dependent cancer or are suspected of having cancer of the prostate or the breast.
  3. You’re suffering from a liver tumor.
  4. Lastly, it is crucial to remember that Nebido is not meant to be used by women.

Other Necessary Warnings and Precautions

Your doctor is likely to perform two tests before and during your medical treatment: testosterone blood level and full blood count. However, in any case, it is essential to inform and consult with your doctor before using Nebido if you have ever had:

  • Heart, kidney, or liver problems
  • Epilepsy
  • Migraine
  • Apnea
  • Any type of cancer
  • Blood clotting problems
  • Thrombophilia
  • Frequent drop or increase in blood pressure
  • Bleeding disorders (i.e., hemophilia)
  • Factors contributing to increasing risk of blood clotting (These may include previous blood clots, obesity, cancer, and immobility)

Here are a few other conditions that you may need to be aware of for your current or future convenience when using Bayer Nebido:

If Your Liver is Not Working

Since there haven’t been any formal studies performed on patients with liver impairment, you’ll not be prescribed Nebido if you have ever had a liver tumor.

For Children and Adolescents

Nebido is not to be used on children or adolescents. Case in point, there is no data available on the medicine’s use for males under eighteen years of age.

For Elderly Patients (65 Years or Older)

Contrary to what people assume, you wouldn’t have to adjust the dose for your medicine when you are over sixty-five.

For Pregnant or Breastfeeding Women

The medicine is not intended for use in women, let alone pregnant or breastfeeding women.

For Fertility

When fertility treatments are combined with high doses of testosterone, it may reversibly reduce or even stop sperm production for a while.

For Muscle Building

Nebido is not considered suitable for perfectly healthy individuals looking to build muscles to increase their physical strength.

Drug Tests, Drug Abuse, and Dependence

Using Nebido may lead to positive results in drug tests.

Moreover, it is advised to take this medicine exactly per your doctor’s or pharmacist’s order. Tampering with the dose, especially if you overdose or take the testosterone with other anabolic androgenic steroids, can cause severe health issues to your liver, heart and blood vessels, or mental health.

Furthermore, individuals abusing testosterone may also become dependent on it, experiencing withdrawal symptoms when the dosage significantly changes or stops immediately.

Medical Examination and Follow-ups

Male hormones can increase the growth rate of prostate cancer or enlarged prostate glands (benign prostatic hypertrophy) for individuals already suffering from these conditions on a smaller scale unknowingly. That’s why doctors always examine and check for these conditions before prescribing Nebido.

These medical check-ups are especially important if you are elderly.

Nebido and Other Medicines

It’s crucial to let your doctor or pharmacist know if you’re using Nebido with any other medicines, including those obtained without a prescription. Your doctor may have to adjust the dose when you’re using any of the following medications:

  • ACTH or corticosteroids – These are used to treat various medical conditions, including rheumatism, allergic conditions, arthritis, and asthma
  • Blood-thinning tablets
  • Diabetes-treating medicines
  • Medicines used for treating blood clots

3- How to Use Nebido?

Initially, your doctor may inject Nebido (1 ampoule/vial) into a muscle at a very slow pace. These doses are generally given to patients every ten to fourteen weeks. It’s essential to note that even though the gap in between the doses is vast, it is enough to maintain sufficient testosterone levels in men without leading to a testosterone build-up in the blood.

Moving on, your doctor will always measure your testosterone levels before injecting the next dose after an interval to ensure there’s no build-up. If your testosterone level is too low during the check-up, your doctor may increase the injection frequency. On the contrary, if your testosterone level is too high, they may decide to lessen the dose frequency. 

It is recommended not to miss or delay your appointments. Otherwise, it would become difficult for your doctor to ensure that your optimum testosterone level is maintained adequately.

Symptoms of Injecting Too Much Nebido

  • Weight gain
  • Nervousness
  • Irritability
  • Frequent or long-lasting erections

4- Possible Side Effects of Using Nebido

Like all medicines, Bayer Nebido can cause a few side effects. However, they usually don’t have an impact on all users.

Common Side Effects (May Occur in Every 1 of 10 Patients)

  • Hot flushes
  • Acne
  • Slight irritation or bruising on the spot where the medicine is injected
  • Weight gain
  • Abnormally high levels of red blood cells
  • Enlarged prostate

Uncommon Side Effects (May Occur in Every 1 of 100 Patients)

  • Allergic reaction
  • Increased appetite
  • Depression, restlessness, or irritability
  • Insomnia
  • Increased blood sugars or fats
  • Hair loss or dry skin
  • Headache, migraine, or tremors
  • Diarrhea or nausea
  • Cardiovascular disorder
  • Sinusitis, cough, snoring, or shortness of breath
  • Urinary tract disorders
  • Prostatic disorders
  • Changes in liver test results
  • Muscle problems, including joint or limb pain, spasm, and stiffness
  • Tiredness
  • Night sweats

Rare Side Effects (May Occur in Every 1 of 1000 Patients)

If this yellow liquid medicine reaches the lungs, it can lead to rare cases of cough fits, temporary shortness of breath, excessive sweating, chest pain, jaundice, or fainting. However, these symptoms often occur right after taking a dose as a side reaction and are reversible. Moreover, a few cases of suspected anaphylactic reactions have also been reported after using Nebido injections.

In addition, some patients may experience more frequent erections initially, which is usually due to an overdose of Nebido. This long-lasting testosterone may also reduce sperm production, even though it always returns to normal once the treatment ceases.

Lastly, like all testosterone products, Nebido poses a common risk of increased red blood cell count, hematocrit and hemoglobin, which can be observed with regular blood tests.

5- How to Store Nebido?

While Bayer Nebido doesn’t need to be stored in any special conditions, it is advised to keep the medicine out of the reach and sight of children.

Furthermore, it would be best not to use this medicine after the passing of the expiry date. The said date is stated after the “EXP” label on the package, referring to the last day of the expiry month.

Hopefully, we’ve covered all the necessary aspects of using Bayer Nebido in this article. For further information, you’re welcome to consult our specialists at HGH Thai by writing to us via email through our website.

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