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During a steroid cycle, Nolvadex is used by bodybuilders who are sensitive to estrogen buildup. Estrogen buildup can lead to many concerns, foremost of these is the occurrence of gynecomastia (growth of breast tissues in men) and subcutaneous fat and water retention. During PCT, Nolvadex is effective in averting the dreaded effect when coming off a steroid cycle – the post-cycle crash. This is basically losing what you have gained when you’re on a cycle. Bodybuilders, in general, use Nolvadex to block this from taking place.