Growth hormone (also referred to as human growth hormone or HGH) is a hormone produced by the pituitary gland that can affect several tissues, including muscle, liver, bone, and cartilage. The important functions of HGH are to regulate the metabolism of fat, protein, and carbohydrate, and to promote the growth of cells and tissues throughout the body.
In this article, we will focus on the beneficial effects of HGH on bone and cartilage (an elastic tissue covering at the joint).
The benefits of HGH on bone and joint
HGH is the most important hormone for bone and cartilage growth since it increases the number of cells that are responsible for bone and cartilage formation. HGH produced from the pituitary gland stimulates the liver to secrete insulin-like growth factor 1(IGF1), which is involved in the proliferation and function of cells, resulting in body growth and development.
According to various experiments and reviews, HGH and IGF1 exert many pros on improving bone and joint condition, including:
- Regulating bone formation and remodeling: HGH directly stimulates the proliferation of osteoblasts (new bone cells), as well as regulates the balance between bone resorption and bone formation. HGH treatment, thus, can increase bone mass and mechanical strength.
- Speeding fracture healing: Bone healing is initiated by the formation woven bone and cartilage at the central area. As HGH stimulates the production of new bone cells and cartilage cells, HGH treatment tends to enhance the rate of fracture healing.
- Improving articular disorders: As promoting cartilage cells production is one of its major roles, some investigations reported that long-term HGH replacement increased bone density and did improve the abnormalities of joint, such as arthritis.
The effects of HGH in adults with growth hormone deficiency
Adults with growth hormone deficiency (or GHD) may have symptoms related to the abnormalities of bone and joint, including:
- Low bone density (leading to the higher risk of osteoporosis and fracture)
- Decreased muscle mass (making bone and joint more susceptible to injury)
- Increased body fat and body weight (pressing more pressure on bone and joint)
The treatment with HGH injection can help people with GHD to:
- Increase bone mass and density
- Increase muscle mass
- Reduce body fat and body weight
- Increase exercise performance
How to replace HGH
People with growth hormone deficiency can get the replacement by injecting HGH or recombinant HGH substances to recall its functions.
GENOTROPIN is a prescription product for the replacement of growth hormone in both children and adults who have GHD, as well as in children with Prader-Willi syndrome, Turner syndrome, Small for gestational age, and idiopathic short stature.
Pfizer GENOTROPIN 36 IU GoQuick Pen is a portable FDA-approved product that is now available in Thailand. Pfizer GENOTROPIN is safe and effective for boosting muscle and bone mass and improving bone and joint physical strength.
However, some people using synthetic growth hormones possibly experience adverse effects, including joint and muscle pain, increased blood sugar levels, and fluid retention (leading to swelling in the legs and arms). So, if needed, you should ask your doctor for the eligibility and dose adjustment.
- Claes Ohlsson, Bengt-Åke Bengtsson, Olle G. P. Isaksson, Troels T. Andreassen, Maria C. Slootweg, Growth Hormone and Bone, Endocrine Reviews, Volume 19, Issue 1, 1 February 1998, Pages 55–79
- Growth Hormone (https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/growth-hormone)